ea0026p56 | Endocrine tumours and neoplasia | ECE2011
Verdelli C
, Donnangelo A
, Vaira V
, Meregalli M
, Belicchi M
, Guarneri V
, Scillitani A
, Vicentini L
, Cetani Filomena
, Ferrero Stefano
, Frigerio Marcello
, Costa Elena
, Ambrosi Bruno
, Torrente Yvan
, Bosari Silvano
, Spada Anna
, Corbetta Sabrina
The embryonic transcription factor TBX1 plays a critical role in cell differentiation during organogenesis of the parathyroid glands. Here we demonstrated that TBX1 mRNA and protein were detected in human adult normal parathyroid tissues (n=3). Immunostaining showed that TBX1 protein was expressed in endothelial CD31+, alfa-SMA+ cells. By contrast, TBX1 mRNA and protein was expressed at higher levels in parathyroid typical adenomas (n=23), where TBX1 staining was...